The spread of CTX-M-type extended-spectrum β-lactamases

CTX-M Extended-spectrum β-Lactamases, Washington State

Our study of risk factors for T. gondii infection was a case-control design to evaluate recent infection, not a cross-sectional study of T. gondii infection prevalence in a population. In our study, case-patients with recent infection were similar in age to T. gondii–negative control-patients, although among women the mean age of case-patients (33 years) differed slightly from that of control-p...

Direct RNA-Based Detection and Differentiation of CTX-M-Type Extended-Spectrum β-Lactamases (ESBL)

The current global spread of multi-resistant Gram-negatives, particularly extended spectrum β-lactamases expressing bacteria, increases the likelihood of inappropriate empiric treatment of critically ill patients with subsequently increased mortality. From a clinical perspective, fast detection of resistant pathogens would allow a pre-emptive correction of an initially inappropriate treatment. ...

Carriage of CTX-M type extended spectrum β-lactamases (ESBLs) in gulls across Europe

BACKGROUND Extended spectrum β-lactamases (ESBLs), a group of enzymes conferring resistance to third generation cephalosporins have rapidly increased in Enterobacteriacae and pose a major challenge to human health care. Resistant isolates are common in domestic animals and clinical settings, but prevalence and genotype distribution varies on a geographical scale. Although ESBL genes are frequen...

Growing Group of Extended-Spectrum -Lactamases: the CTX-M Enzymes

Molecular Basis for the Catalytic Specificity of the CTX-M Extended-Spectrum β-Lactamases

Extended-spectrum β-lactamases (ESBLs) pose a threat to public health because of their ability to confer resistance to extended-spectrum cephalosporins such as cefotaxime. The CTX-M β-lactamases are the most widespread ESBL enzymes among antibiotic resistant bacteria. Many of the active site residues are conserved between the CTX-M family and non-ESBL β-lactamases such as TEM-1, but the residue...